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Aging is one of life’s unfortunate, but inevitable facts: we might be able to disguise the wrinkles for a time, but we will all start to feel the effects of aging sooner or later.
Longevity scientists have been searching for molecules that could potentially extend our healthspan (the number of years we remain in good health). And NMN supplements are touted as one of the most promising agents to support healthy aging.
Taking NMN supplements boosts NAD+ levels which has been shown to have potent health benefits in animal studies. In essence, boosting NAD+ levels triggers a shift in our cells that enhances survival, including boosting energy production and upregulating cellular repair.
Naturally, there’s a huge amount of interest in NMN supplements and with that, there are a number of different brands on the market. The best NMN supplements will contain the highest purity ingredients without any unnecessary additives. Some NMN supplements will also contain other well-known anti-aging ingredients to maximise the overall benefit.
We’ve put together a list of the best NMN supplements based on ingredient quality, dosage and value for money.
What makes a top NMN supplement?
When it comes to choosing a top NMN supplement, there are only a few considerations that you need to be aware of.
Purity
The best NMN supplements will contain a minimum of 98% purity NMN.
Dose
The ideal NMN dose is not yet known and will be unique to every person. Research studies often use doses between 300 – 900mg and this is the range you’ll often see in the best available NMN brands
Quality
Always look for brands that manufacture NMN in a GMP certified (good manufacturing practice) facility. In addition, some brands will also send their product for 3rd party testing which double checks the purity and dose. You’ll also want to avoid any fillers or packing agents so that you only consume the ingredients you need.
Other anti-aging ingredients
Although NMN is arguably one of the best anti-aging molecules available, there are many other research-backed ingredients to be aware of. That’s why some supplements will combine NMN with other anti-aging ingredients such as Resveratrol, Fisetin, Spermidine, Quercetin and other antioxidants.
With this in mind, here is a list of some of the best NMN supplements around right now.
Top pick of the 5 Best NMN Supplements
#1 OMRE NMN + Resveratrol
HCMarketing
NMN Purity: 98%
NMN dose: 500mg
Quality:
- Made in the USA
- GMP certified facility
- 3rd party tested
- magnesium stearate or silicon dioxide
- 30-day money back guarantee
Other ingredients:
- Resveratrol 500mg (98% purity)
- BioPerine® 5mg
Price: $59.97
OMRE combines high purity NMN with Resveratrol which is another potent anti-aging ingredient. In addition, they include BioPerine® which is a patented bioavailability enhancer. Essentially, BioPerine® improves the absorption of other ingredients. Studies have show it can potentially increase the absorption of resveratrol by over 10x. (1)
OMRE uses veggie capsules and avoids additives like magnesium stearate and silicon dioxide. Furthermore, their product is manufactured in the USA in a facility that’s FDA and GMP registered.
Check the latest price on OMRE website
#2 Tonniq NMN + Resveratrol + Trimethylglycine
HCMarketing
NMN Purity: 98%
NMN dose: 500mg
Quality:
- Veggie capsule
- 3rd party tested
- 60-day money back guarantee
Other ingredients:
- Resveratrol 500mg (98% purity)
- Betaine anhydrous 500mg
Price: $59.99
Toniiqs elixir blends NMN with Resveratrol and Trimethylglycine. Trimethylglycine is naturally occurring methyl donor, that restores methionine homeostasis in cells.
They randomly batch test their products to guarantee quality and offer a 60 day money back guarantee.
Check the latest price on Toniiq website
#3 RENUE By Science Liposomal NMN
HCMarketing
NMN Purity: 98%
NMN dose: 500mg
Quality:
- Liposomal NMN
- GMP certified facility
- 3rd party tested
- magnesium stearate or silicon dioxide
Price: $84.95
Renue by science uses a powder-based liposome formula to enhance absorption. The claim is that this delivery method protects NMN from digestive enzymes. With this novel delivery system comes a premium price tag which may not be suitable to everyones budget. Nevertheless, it’s a top rated NMN supplement from a reputable brand.
Check the latest price on RENUE website
#4 Pro Health Longevity NMN
HCMarketing
NMN Purity: 99%
NMN dose: 500mg
Quality:
- 75-day money back guarantee
- Made in the USA
- 3rd party tested
- magnesium stearate or silicon dioxide
Price: $58
ProHealth uses a patented NMN source from Uthever which claims over 99% purity. This supplement does not contain any additives like magnesium steararte. Instead, they use brown rice powder which is a natural alternative.
ProHelath sells a range of NMN forms such as lozenges, capsules and powders to suit all consumer needs.
Check the latest price on PROHEALTH website
#5 Double Wood NMN
HCMarketing
NMN Purity: 98%
NMN dose: 250mg
Quality:
- Bulk discounts
- Made in the USA
- 3rd party tested
Price: $49
Double woods is a brand that has been producing high quality supplements for many years now. They are a company with lots of experience and a strong reputation.
The capsules they use are Gelatin based so are not suitable for those who are vegetarian or vegan.
Check the latest price on DOUBLE WOOD website
What is NMN?
NMN is short for nicotinamide mononucleotide. It’s a micronutrient and derivative of vitamin B3 that we all produce in our cells and is also present in various foods such as avocado, broccoli and edamame.
In fact, vitamin B3 is converted into NMN (in several steps). That’s why people often ask if NMN and vitamin B3 are the same thing. But they are not. Vitamin B3 is just one of the building blocks required to make NMN.
In our cells, two NMN molecules are combined to for NAD+. Hence why taking NMN supplements boosts NAD+ levels.
And NAD+ is involved in many cellular processes, including energy metabolism and DNA repair. As we age, the levels of NAD+ in the body decrease, leading to a decline in these processes and potentially contributing to age-related diseases.
NMN supplements – what are they good for?
Over the last 20 years, several animal studies have shown that boosting NAD+ levels has a significant positive impact on the hallmarks of aging.
What are the hallmarks of aging?
The list can be long, but it all boils down to the following 4 factors which are the key hallmarks of aging to be aware of:
1 – Increased levels Inflammation
2 – Reduced insulin sensitiity
3 – Reduced mitochondrial function
4 – Gene instability and impaired DNA repair
There are many NAD+ boosting ingredients. But NMN is seen as the most powerful because it’s a direct precursor to NAD+.
The research into the benefits of NMN supplementation in humans is actively ongoing. But in animal studies, it’s been shown to slow down and even reverse the hallmarks of aging. (2)
So even though its not yet proven to have benefits in humans, there are high hopes for NMN’s potential.
Does NMN actually work?
A human clinical trial looked at excactly this question in 2022. The study involved 80 middle-aged healthy adults randomized for a 60-day clinical trial with once daily oral dosing of placebo, 300 mg, 600 mg, or 900 mg NMN.
They looked at the following things:
- measured blood NAD+ levels
- Safety and tolerability of taking NMN supplements
- Measured physical performance based on a standardised 6-minute walking test.
- Blood biological age
- Insulin sensitivity
And the results were fascinatiing. Here’s what they found after 60 days:
- NAD+ levels increased significantly compared to placebo in all doses (300-900mg)
- reported side ffects. Well-tolerated
- 6-minute walking test improved in all groups compared to placebo with a peak at 600mg daily dose.
- Blood biological age increased in placebo but stayed the same in all the people taking NMN (all doses).
- Insulin sensitivity – no significant change in those taking NMN compared to placebo.
Interestingly, a significant benefit was seen even at a smaller dose of 300mg in most parameters. And a dose of 600mg had the biggest impact on physical performance.
It’s important to highlight that this was a small study of only 80 people. So a lot more research needs to be done. But the initial findings are very promising.
What’s the ideal NMN supplement dosage?
It’s not yet known what the ideal NMN supplement dose is. But going off the study mentioned above, it’s clear that even a smaller dose of 300mg has a significant benefit over placebo.
The best NMN supplements will include a dose of around 500mg which is in the middle of the range used in research studies.
And realistically, the ideal NMN dose is going to vary from person to person.
The most accurate way of finding out the best NMN dose for you is to test your blood parametrs and biological age. This is easier said than done and can be costly.
Alternatively, you could consider starting with a smaller dose and see how you respond.
Is it safe to take NMN daily?
As we’ve already alluded to, there are only a handful of studies in humans and most have looked at giving daily NMN over a period of up to 3-4 months.
Thus far, no particular concerns have been raised and longer studies are ongoing. And we wont know long term safety results for at least a few years from now. (3)
How long does it take for NMN to start working?
In the studies so far, NMN starts to boost NAD+ levels in as little as a few weeks and certainly by 30 days.
How long this takes to translate into observable and measurable health benefits is as yet unknown.
The study we mentioned above reports improved walking distance and blood biomarkers of agining seen after 2 months.
Realistically, noticeable benefits will probably take a lot longer than this. As with all things health related, very little changes over night!
Is it better to take NMN supplements in the morning or at night?
Harvard professor Dr David Sinclair and his colleagues recommend taking NMN supplements in the morning.
That’s because our cells naturally produce more NAD+ in the morning and levels decline by the time it’s evening.
So to match your cells biology, taking NMN supplements in the morning makes the most sense.
How well are NMN supplements absorbed?
Unlike other supplements where absorption is often an issue, NMN quickly absorbed from the gut into blood circulation within 2–3 min and then into your cells within 15 min.
Some brands sell NMN in liposomal format which may enhance absorption even further. But even standard powdered or capsule NMN supplements achieve excellent absorption.
What is the best way to get NMN?
Getting a high enough amount of NMN from food sources is very difficult.
To put it into perspective, tomatoes and avocados contain between 0.36 and 1.6mg of NMN per 100g. (4)
NMN supplements on the other hand contain anywhere between 300-1000mg of NMN.
That means an average avocado weighing 200g will contain around 2mg of NMN. You’d need to eat around 250 avocados to obtain 500mg of NMN.
So the best way to get enough NMN to make an impact is only through supplements. It’s not possible to achieve a high enough dose from your diet to impact NAD+ levels.
How to choose the right NMN supplement
Consider Your Goals
Before you begin your search, consider what you’d like your NMN supplement achieve. Do you want a specific NMN dose? Are you hoping to combine other anti-aging ingredients? What are your current barriers to health? weight loss: an insatiable appetite, a lack of motivation in the gym, or something else?
Understanding your goals can help you look for NMN supplements with the appropriate benefits. It’s always important to remember that NMN supplements are not the magic elixir of youth and there are lots of other and arguably, more important factors to good health.
Check Ingredients Closely
The best NMN products will not only contain high purity NMN, but also avoid the use of any artificial additives. When you’re purchasing NMN supplements, it’s not just the NMN itself you should be thinking of. Does it contain any fillers or additives like magnesium stearate? Is the capsule made from vegetable cellulose or animal based gelatin? Are there any other unexpected ingredients listed?
All of this matters when you want to differentiate the best NMN supplements. And it’s not easy to tell most of the time because this information is usually listed in small print on the back of the label.
Look For Discounts
NMN supplements can range in price from under $30 a bottle to over $100 a bottle. Most of the supplements above fall in a moderate price range of around $50 to $90 for a one-month supply.
Many companies also offer discounts for new customers or when you order in multi-packs.
NMN supplements are designed to be taken continuously. It is highly unlikely you’ll notice any difference within a few weeks, the same reason why won’t have a 6 pack after going to the gym for a month.
Look For Money-Back Guarantees
Look out for money-back guarantees which adds another layer of protection if you decide NMN isn’t right for you. The 4 best NMN brands we’ve picked all offer a no quibble money-back guarantee. Reputable brands will always back themselves and the quality of the products they sell.
Look Out For Fakes
NMN is an expensive ingredient. It’s not the same as your run of the mill B complex or vitamin C that you may purchase for cheap on Amazon. With this comes a premium price tag. You may come across NMN supplements that are very cheap, but always question the accuracy and quality of their product.
How can I get the best results with NMN supplements?
NMN is not a magic supplement that’s going to solve your health and longevity goals. There are several lifestyle factors that boost NAD+ levels naturally which you should consider alongside taking NMN supplements.
These include:
Dietary restriction (AKA Intermittent fasting)
Intermittent fasting has gained popularity in recent years for its potential health benefits, including its possible impact on longevity. While the exact mechanisms are still being studied, here are some ways in which intermittent fasting may contribute to improved longevity:
- Cellular Repair and Autophagy: During periods of fasting, the body goes through a process called autophagy, which involves the breakdown and recycling of old and damaged cells. This cellular repair mechanism helps remove dysfunctional components and promotes the regeneration of healthier cells, potentially reducing the risk of age-related diseases.
- Insulin Sensitivity and Blood Sugar Regulation: Intermittent fasting can improve insulin sensitivity, the body’s ability to respond to insulin and regulate blood sugar levels. By reducing insulin resistance, Intermittent fasting may help lower the risk of type 2 diabetes and other metabolic disorders that are associated with reduced longevity.
- Reduced Inflammation: Chronic inflammation is linked to various age-related diseases, including cardiovascular disease, cancer, and neurodegenerative disorders. Intermittent fasting has been found to reduce inflammation markers in the body, which may contribute to improved longevity by lowering the risk of these diseases.
- Enhanced Cellular Stress Resistance: Intermittent fasting induces a mild form of stress on cells, similar to what happens during exercise. This cellular stress response activates various protective mechanisms, such as increased production of antioxidants and stress-resistant proteins, which can improve the resilience of cells and potentially slow down the aging process.
- Weight Management: Intermittent fasting can help with weight loss and weight maintenance. Obesity is associated with numerous health complications and a shorter lifespan. By promoting weight loss and a healthier body composition, Intermittent fasting may help improve longevity and reduce the risk of obesity-related diseases.
If you do plan to start a fasting regimen, you must speak to your doctor first to make sure it is safe for you to do so. It is not suitable for some people and does not come without risks.
High intensity exercise
High-intensity exercise has been shown to have several positive effects on longevity. High intensity exercise can mean different things to different people. But in essence, it describes a form of exercise that involves bursts of activity, followed by short rest periods. So it can take any shape of form and be achieved with all forms of exercise. Here are some ways in which it may contribute to improved longevity:
- Cardiovascular Health: High-intensity exercise, such as aerobic activities like running or cycling at a vigorous pace, can improve cardiovascular health by increasing heart strength, reducing blood pressure, improving blood lipid profiles, and enhancing overall cardiac function. Regular engagement in high-intensity exercise can reduce the risk of heart disease, the leading cause of death worldwide.
- Metabolic Health: High-intensity exercise can improve metabolic health by increasing insulin sensitivity and promoting glucose regulation. It can help manage body weight, reduce abdominal fat, and improve lipid profiles. These benefits are particularly relevant for reducing the risk of type 2 diabetes and metabolic syndrome, both of which are associated with decreased longevity.
- Muscle Strength and Bone Density: High-intensity exercise, including resistance training, can increase muscle strength, power, and mass. It also stimulates the production of bone tissue, leading to improved bone density. Maintaining strong muscles and bones is crucial for preventing age-related conditions such as sarcopenia (muscle loss) and osteoporosis (loss of bone density), which can impact longevity and quality of life.
- Hormonal and Cellular Benefits: High-intensity exercise stimulates the release of hormones, such as growth hormone and testosterone, which play important roles in maintaining muscle mass, bone density, and overall vitality. Additionally, high-intensity exercise can enhance mitochondrial function, increase antioxidant capacity, and stimulate the production of proteins involved in cellular repair and stress resistance. These cellular adaptations contribute to improved overall health and may help slow down the aging process.
- Cognitive Function: Regular engagement in high-intensity exercise has been linked to improved cognitive function and a reduced risk of neurodegenerative disorders, such as Alzheimer’s disease. Exercise promotes neuroplasticity, the ability of the brain to form new connections and adapt, which can enhance memory, attention, and overall cognitive performance.
Improve sleep quality
Some scientis would argue that the best way to enhance longevity is to improve your sleep. There is now ample evidence to suggest that poor sleep is linked with a variety of negative health outcomes, inclduing premature death.
If you’re thinking of taking NMN supplements as part of your daily routine, you should also consider optimizing your sleep as a first step.
Simple things like avoiding screens after dark, drinking less caffeine and removing distractions from your bedroom can have a big impact on your sleep quality. Avoiding alcohol before bed is also very important as it blocks your brain from entering REM sleep.
Optimize diet for longevity
There’s no point of investing in NMN supplements if you don’t also invest in improving your diet. The best diet for longevity is a topic of ongoing research, and there is no single “one-size-fits-all” approach. However, several dietary patterns have been associated with improved longevity and overall health. Here are some dietary principles that are often recommended for promoting longevity:
- Plant-Based Foods: Emphasize a diet rich in fruits, vegetables, whole grains, legumes, nuts, and seeds. These foods are packed with essential nutrients, antioxidants, and fiber while being generally lower in calories and saturated fats.
- Mediterranean Diet: The Mediterranean diet is characterized by a high consumption of fruits, vegetables, whole grains, legumes, nuts, and olive oil. It also includes moderate amounts of fish, poultry, and dairy products while limiting red meat and processed foods. This dietary pattern has been associated with lower risks of heart disease, certain cancers, and neurodegenerative diseases.
- Healthy Fats: Focus on consuming sources of healthy fats, such as avocados, olive oil, nuts, and seeds, while limiting saturated and trans fats. Healthy fats have been linked to improved cardiovascular health and reduced inflammation.
- Reduced Sugar and Processed Foods: Minimize the consumption of added sugars and processed foods, as they are often low in nutrients and high in calories, unhealthy fats, and artificial additives. High sugar intake has been associated with an increased risk of obesity, diabetes, and heart disease.
NMN supplement side effects
There is limited research on the safety and side effects of NMN supplements, but some studies have reported mild side effects. These side effects include:
- Gastrointestinal issues: Some people may experience nausea, vomiting, diarrhea, or abdominal discomfort.
- Headache: NMN supplements may cause headaches in some people.
- Fatigue: Some people may experience fatigue or drowsiness after taking NMN supplements.
- Flushing: NMN may cause flushing or redness in the face.
- Dizziness: In rare cases, NMN supplements may cause dizziness or lightheadedness.
It’s important to note that these side effects are generally mild and temporary, and don’t occur in most people who take NMN supplements.
However, it’s always advisable to talk to a healthcare professional before taking any new supplement, especially if you have any underlying health conditions or are taking medications. Additionally, it’s essential to follow the recommended dosage guidelines and not start off with a very high dose, as excessive intake may increase the risk of adverse effects.
What are the downsides of NMN?
While there is some promising research on the benefits of NMN, there are also potential downsides to its use. Some of these downsides include:
- Limited research: While there have been some studies on NMN, there is still limited research on its long-term safety and efficacy in humans. This means that there may be unknown risks associated with its use.
- High cost: NMN supplements can be quite expensive, which may make them inaccessible to some people.
- Interactions with medication: NMN may interact with certain medications, particularly those that affect the liver or the immune system.
- Uncertain dosing: There is no established dosing regimen for NMN, and the optimal dose may vary depending on the individual. This makes it difficult to determine the appropriate amount to take and may increase the risk of side effects or other complications.
FAQ’s
Here are some of the most common questions people have about NMN supplements
Is NMN better than NR?
NR (nicotinamide riboside) is the precursor the NMN. So its one step further away from NAD+.
While both NMN and NR have been studied for their potential health benefits, there is currently no clear evidence to suggest that one is definitively better than the other.
Some studies suggest that NMN may be more effective than NR at increasing NAD+ levels in certain tissues and organs, such as the liver and muscle tissue. Other studies have found that NR may be more effective than NMN at increasing NAD+ levels in the brain and peripheral nervous system.
However, these findings are still preliminary, and more research is needed to fully understand the differences between NMN and NR and their effects on NAD+ metabolism and health.
Is NMN better than Resveratrol?
Unlike comparing NMN to NR, it’s more difficult to compare NMN to Resveratol because they are very different compounds.
Resveratrol is a polyphenol that is found in certain foods such as grapes, peanuts, and red wine. In essence, it’s a plant-based antioxidant.
The anti-aging property of Resveratrol is linked to the fact it is a sirtuin activator. These are a family of enzymes that are involved in cell metabolism and aging. And Resveratrol has been shown to greatly upregulate the activity of sirtuins and indirectly boost NAD+ levels. (5)
While NMN’s only function is to boost NAD+ levels. Resveratrol boosts NAD+ in addition to having several other benefits such as antioxidation, sirtuin activation and reducing inflammation.
That’s why some of the best NMN brands also include Resveratrol to provide an all-round potent anti-aging supplement.
Does NMN make you look younger?
A few studies have investigated the effects of NMN supplementation on skin aging in mice. One study found that NMN supplementation helped to improve skin barrier function and reduce wrinkle formation in mice. Another study found that NMN supplementation helped to improve skin elasticity and reduce collagen degradation in mice.
However, it’s important to note that these studies were conducted in mice, and more research is needed to fully understand the effects of NMN supplementation on skin aging in humans. Additionally, there are many factors that contribute to the aging process, and it’s unlikely that NMN supplementation alone can completely reverse the effects of aging or make a person look younger.
Which NMN supplement does David Sinclair use?
Harvard professor Dr Sinclair is arguably one of the best-known advocates of NMN supplements. His research has paved the way into identifying NMN as one of the best supplements to support healthy aging. He openly states that he takes 1000mg of NMN with 1000mg of Resveratrol every day.
But he doesn’t say which specific NMN brand he uses. In reality, the specific NMN supplement that David Sinclair takes is not so important. Ultimately, all that matters is whether the NMN purity is high and from a reputable manufacturer.
Can I take NMN on an empty stomach?
If you practice intermittent fasting, you’ll want to know if you can take NMN on an empty stomach.
The short answer is, yes you can. NMN is absorbed well through the gut, even on an empty stomach.
Some people may experience some abdominal discomfort when taking NMN on an empty stomach, in which case taking it with food will mitigate this problem. But the vast majority of people will have no issues with taking NMN on an empty stomach.
What is the best age to start taking nmn supplements?
There is no specific age at which it is recommended to start taking NMN (nicotinamide mononucleotide) supplements, as the effects of aging and the rate at which NAD+ levels decline can vary among individuals.
Some studies have shown that NAD+ levels begin to decline as early as in our 20s, while others have found that NAD+ levels decline more rapidly after the age of 50. Therefore, some people may choose to start taking NMN supplements earlier in life as a preventative measure, while others may start later when they begin to notice age-related changes.
Best NMN supplements Conclusion
So there you have it, that wraps up our review of the best NMN supplements on the market.
We’ve walked you through some of the key things to look our for when buying NMN supplements and have picked out a handful of the top NMN brands on the market right now.
But there are other great options on the market so long as you make sure to look out for a reputable brand that contains high purity NMN thats manufactuerd in a GMP certified facility without any additives.
This is sponsored content. M&F is not endorsing the websites or products listed in this article.
